Title: Aptiganel
CAS Registry Number: 137159-92-3
CAS Name: N-(3-Ethylphenyl)-N-methyl-N¢-1-naphthalenylguanidine
Additional Names: N-(1-naphthyl)-N¢-(3-ethylphenyl)-N¢-methylguanidine; aptaguanal
Molecular Formula: C20H21N3
Molecular Weight: 303.40
Percent Composition: C 79.17%, H 6.98%, N 13.85%
Literature References: Noncompetitive NMDA-receptor antagonist. Prepn: E. Weber, J. F. W. Keana, WO 9112797; eidem, US 5262568 (1991, 1993 both to State of Oregon); N. L. Reddy et al., J. Med. Chem. 37, 260 (1994). Clinical pharmacology and kinetics: K. W. Muir et al., Ann. N.Y. Acad. Sci. 765, 279 (1995). Review of theoretical basis for use in stroke: K. W. Muir, K. R. Lees, Stroke 26, 503-513 (1995). Clinical trial in acute ischemic stroke: G. W. Albers et al., J. Am. Med. Assoc. 286, 2673 (2001).
Derivative Type: Hydrochloride
CAS Registry Number: 137160-11-3
Manufacturers' Codes: CNS-1102
Trademarks: Cerestat (Cambridge Neurosci.)
Molecular Formula: C20H21N3.HCl
Molecular Weight: 339.86
Percent Composition: C 70.68%, H 6.52%, N 12.36%, Cl 10.43%
Properties: Off-white needles from ethanol + diethyl ether, mp 223-225°.
Melting point: mp 223-225°
Therap-Cat: Neuroprotective.
Keywords: Neuroprotective; NMDA Receptor Antagonist. |