Ciprofibrate, Win-35833, Modalim, Hiperlipen, Lipanor, Ciprol-药物合成数据库

【药物名称】Ciprofibrate, Win-35833, Modalim, Hiperlipen, Lipanor, Ciprol

化学结构式(Chemical Structure):

参考文献No.	53434
标题:	Ciprofibrate
作者:	Casta馿r, J.; Hillier, K.
来源:	Drugs Fut 1977,2(5),297

合成路线图解说明: The Sandmeyer reaction of 4-(2',2'-dichlorocyclopropyl)aniline (I) first with NaNO2 and acetic acid and then with 33% aqueous H2SO4 at 100 C gives 4-(2',2'-dichlorocyclopropyl)phenol (II), which is then condensed with acetone (A) and CHCl3 by means of NaOH in refluxing acetone.

参考文献No.	701081
标题:	Phenoxyacetic acid and cyclopropa-alpha-naphthoxyacetic acid derivatives
作者:	Phillips, D.K.
来源:	DE 2343606; FR 2197586; GB 1385828; JP 58074636

合成路线图解说明: The Sandmeyer reaction of 4-(2',2'-dichlorocyclopropyl)aniline (I) first with NaNO2 and acetic acid and then with 33% aqueous H2SO4 at 100 C gives 4-(2',2'-dichlorocyclopropyl)phenol (II), which is then condensed with acetone (A) and CHCl3 by means of NaOH in refluxing acetone.