Bambuterol, KWD-2183, Bambec-药物合成数据库

【药物名称】Bambuterol, KWD-2183, Bambec

化学结构式(Chemical Structure):

参考文献No.	42029
标题:	Bronchospamolytic carbamate derivatives
作者:	Olsson, O.A.T.; Svensson, L.A.; Wetterlin, K.I.L. (Draco L鋕emedel AB)
来源:	DD 202001; EP 0043807; JP 8240453; US 4419364; US 4451663

合成路线图解说明: The reaction of 3,5-dihydroxyacetophenone (I) with N,N-dimethylcarbamoyl chloride (II) in hot pyridine gives 3,5-bis(N,N-dimethylcarbamoyloxy) acetophenone (III), which is brominated with Br2 in dioxane yielding 3,5-bis(N,N-dimethylcarbamoyloxy)phenacyl bromide (IV). The condensation of (IV) with N benzyl-tert butylamine (V) in refluxing acetone affords the corresponding w-amino derivative (VI), which is finally hydrogenated with H2 over Pd/C in ethanol.

参考文献No.	70648
标题:	Bambuterol
作者:	Casta馿r, J.; Prous, J.
来源:	Drugs Fut 1986,11(7),553

合成路线图解说明: The reaction of 3,5-dihydroxyacetophenone (I) with N,N-dimethylcarbamoyl chloride (II) in hot pyridine gives 3,5-bis(N,N-dimethylcarbamoyloxy) acetophenone (III), which is brominated with Br2 in dioxane yielding 3,5-bis(N,N-dimethylcarbamoyloxy)phenacyl bromide (IV). The condensation of (IV) with N benzyl-tert butylamine (V) in refluxing acetone affords the corresponding w-amino derivative (VI), which is finally hydrogenated with H2 over Pd/C in ethanol.