*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : MF3683000
CHEMICAL NAME           : Guanidine, methyl-
CAS REGISTRY NUMBER     : 471-29-4
LAST UPDATED            : 199203
DATA ITEMS CITED        : 4
MOLECULAR FORMULA       : C2-H7-N3
MOLECULAR WEIGHT        : 73.12
COMPOUND DESCRIPTOR     : Mutagen
SYNONYMS/TRADE NAMES :
   * Methylguanidin
   * Methylguanidine
   * Monomethyl guanidin
   * Monomethylguanidine
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 250 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   85KYAH "Merck Index; an Encyclopedia of Chemicals, Drugs, and Biologicals",
   11th ed., Rahway, NJ 07065, Merck & Co., Inc. 1989 Volume(issue)/page/year:
   11,957,1989
 
TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Unreported
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 20 mg/kg
TOXIC EFFECTS :
   Behavioral - convulsions or effect on seizure threshold
   Behavioral - ataxia
   Lungs, Thorax, or Respiration - other changes
REFERENCE :
   ZEPHAR Zentralblatt fuer Physiologie.  (Leipzig, Ger. Dem. Rep.)  V.1-34,
   1887-1921.  For publisher information, see PFLABK. Volume(issue)/page/year:
   25,441,1911
 
                            ** MUTATION DATA **
 
TYPE OF TEST            : Cytogenetic analysis
TEST SYSTEM             : Rodent - hamster Fibroblast
DOSE/DURATION           : 1 gm/L/48H
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 48,337,1977

                          *** STATUS IN U.S. ***
 
   EPA GENETOX PROGRAM 1988, Negative: In vitro UDS-human fibroblast

 
                            *** END OF RECORD ***