Grignard Degradation

W. Steinkopf et al., Ann. 512, 136 (1934); 543, 128 (1940).

Stepwise dehalogenation of a polyhalo compound through its Grignard reagent which on treatment with water yields a product containing one halogen atom less:

V. Grignard, Compt. Rend. 130, 1322 (1900); F. F. Blicke, Heterocyclic Compounds 1, 222 (1950); K. Nützel, Houben-Weyl 13/2a, 128 (1973).