Hammick Reaction

P. Dyson, D. L. Hammick, J. Chem. Soc. 1937, 1724.

Decarboxylation of α-picolinic or related acids in the presence of carbonyl compounds accompanied by the formation of a new carbon-carbon bond:

D. L. Hammick et al., J. Chem. Soc. 1939, 809; 1949, 659; N. H. Cantwell, E. V. Brown, J. Am. Chem. Soc. 75, 1489 (1953); M. J. Betts, B. R. Brown, J. Chem. Soc. 1967, 1730; E. V. Brown, M. B. Shambhu, J. Org. Chem. 36, 2002 (1971). Effect of conditions on yield and products: V. P. Karandikar et al., Indian J. Technol. 23, 28 (1985). Mechanism: R. Grigg et al., J. Chem. Soc. Perkin Trans. II 1990, 51; B. Bohn et al., Heterocycles 37, 1731 (1994).