Hoch-Campbell Aziridine Synthesis

J. Hoch, Compt. Rend. 198, 1865 (1934); K. N. Campbell, J. F. McKenna, J. Org. Chem. 4, 198 (1939).

Formation of aziridines by treatment of ketoximes with Grignard reagents and subsequent hydrolysis of the organometallic complex:

K. N. Campbell et al., J. Org. Chem. 8, 99, 103 (1943); 9, 184 (1944); J. P. Freeman, Chem. Rev. 73, 283 (1973); O. C. Dermer, G. E. Ham, Ethylenimine and Other Aziridines (Academic Press, New York, 1969) pp 65-68; E. Y. Takehisa et al., Chem. Pharm. Bull. 24, 1691 (1976); T. Sasaki et al., Heterocycles 11, 235 (1978); G. Alvernhe, A. Laurent, J. Chem. Res. (S) 1978, 28.