Kröhnke Oxidation

F. Kröhnke et al., Ber. 69, 2006 (1936); 71, 2583 (1938); 72, 440 (1939).

Transformation of activated halides into aldehydes via their pyridinium salts, which yield nitrones upon treatment with p-nitrosodimethylaniline. Aldehydes or ketones are generated upon hydrolysis:

A. A. Goldberg, H. A. Walker, J. Chem. Soc. 1954, 2540; F. Kröhnke, Angew. Chem. Int. Ed. 2, 380 (1963); A. Markovac et al., Heterocyclic Chem. 14, 19 (1977); I. Maeba et al., J. Chem. Soc. Perkin Trans. I 1991, 939; S. N. Kilenyi, Comp. Org. Syn. 7, 657-659 (1991). Cf. Sommelet Reaction.