Niementowski Quinazoline Synthesis

S. v. Niementowski, J. Prakt. Chem. [2] 51, 564 (1895).

Formation of 4-oxo-3,4-dihydroquinazolines by cyclization of the reaction products of anthranilic acid and amides:

Reviews: T. A. Williamson, Heterocyclic Compounds 6, 331 (1957); W. L. F. Armarego, Advan. Heterocyclic Chem. 1, 253 (1963); E. Cuny et al., Tetrahedron Letters 21, 3029 (1980).