Riehm Quinoline Synthesis

P. Riehm et al., Ber. 18, 2245 (1885); 19, 1394 (1886); idem, Ann. 238, 9 (1887).

Formation of quinoline derivatives by prolonged heating of arylamine hydrochlorides with ketones with or without use of aluminum chloride or phosphorus pentachloride:

E. Knoevenagel et al., Ann. 55, 1923, 1934 (1922); 56, 2414 (1923); C. Hollins, The Synthesis of Nitrogen Ring Compounds (London, 1924) p 263; D. J. Craig, J. Am. Chem. Soc. 60, 1458 (1938); R. C. Elderfield, J. R. McCarthy, ibid. 73, 975 (1951); R. C. Elderfield, Heterocyclic Compounds 4, 16 (1952).