Haworth Methylation

W. N. Haworth, J. Chem. Soc. 107, 13 (1915).

Formation of methylated methyl glycosides from monosaccharides with dimethyl sulfate and 30% sodium hydroxide. The glycosidic methyl group is hydrolyzed with acid to yield the free methylated sugar:

W. N. Haworth, H. Machemer, J. Chem. Soc. 1932, 2270; C. C. Barker et al., ibid. 1946, 783; E. J. Bourne, S. Peat, Advan. Carbohyd. Chem. 5, 146 (1950); W. Pigman, The Carbohydrates 1957, 369. Cf. Purdie Methylation.