Cocoyl Caprylocaprate

(Ph. Eur. monograph 1411)

Excipient.

Ph Eur

Mixture of esters of saturated C₁₂ - C₁₈ alcohols with caprylic (octanoic) and capric (decanoic) acids obtained by the reaction of these acids with vegetable saturated fatty alcohols.

Slightly yellowish liquid.

Practically insoluble in water, miscible with ethanol (96 per cent) and with liquid paraffin.

About 0.86.

About 1.445.

About 11 mPa·s.

A. Freezing point (2.2.18): maximum 15 °C.

B. Infrared absorption spectrophotometry (2.2.24).

Comparison   cocoyl caprylocaprate CRS.

C. Composition of fatty acids and fatty alcohols (see Tests).

The substance to be examined is not more intensely coloured than reference solution Y₅ (2.2.2, Method I).

Maximum 0.5, determined on 5.00 g.

Maximum 5.0.

Maximum 1.0.

160 to 173.

Use the chromatogram obtained with the following reference solution for identification of the peaks due to the fatty alcohols.

Reference solution  Dissolve the amounts of the substances listed in the following table in 10 mL of heptane R.

Consider the sum of the areas of the peaks due to the fatty acids listed below to be equal to 100 and the sum of the areas of the peaks due to the fatty alcohols listed below to be equal to 100.

• — caproic acid: maximum 2.0 per cent,

• — caprylic acid: 50.0 per cent to 80.0 per cent,

• — capric acid: 20.0 per cent to 50.0 per cent,

• — lauric acid: maximum 3.0 per cent,

• — myristic acid: maximum 2.0 per cent.

• — capric alcohol: maximum 3.0 per cent,

• — lauryl alcohol: 48.0 per cent to 63.0 per cent,

• — myristyl alcohol: 18.0 per cent to 27.0 per cent,

• — cetyl alcohol: 6.0 per cent to 13.0 per cent,

• — stearyl alcohol: 9.0 per cent to 16.0 per cent.

Maximum 0.1 per cent, determined on 5.00 g.

Maximum 0.1 per cent, determined on 1.0 g.

Ph Eur