Calcium Gluceptate
Glucoheptonic acid, calcium salt (2:1). Calcium glucoheptonate (1:2) ![]() ![]() ![]() » Calcium Gluceptate is anhydrous or contains varying amounts of water of hydration. It consists of the calcium salt of the alpha epimer of glucoheptonic acid or of a mixture of the alpha and beta epimers of glucoheptonic acid. It contains not less than 95.0 percent and not more than 102.0 percent of C14H26 CaO16, calculated on the dried basis.
Packaging and storage
Preserve in well-closed containers.
Labeling
Label it to indicate whether it is hydrous or anhydrous; if hydrous, label it to indicate also the degree of hydration.
Identification
B:
A solution (1 in 50) responds to the tests for Calcium
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pH
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Loss on drying
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Chloride
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Sulfate
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Heavy metals
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Reducing sugars
Dissolve 0.50 g in 10 mL of hot water, add 2 mL of 3 N hydrochloric acid, boil for about 2 minutes, and cool. Add 5 mL of sodium carbonate TS, allow to stand for 5 minutes, dilute with water to 20 mL, and filter. Add 5 mL of the clear filtrate to about 2 mL of alkaline cupric tartrate TS, and boil for 1 minute: no red precipitate is formed immediately.
Assay
Dissolve about 800 mg of Calcium Gluceptate, accurately weighed, in 150 mL of water containing 2 mL of 3 N hydrochloric acid. While stirring, preferably with a magnetic stirrer, add about 25 mL of 0.05 M edetate disodium VS from a 50-mL buret. Add 15 mL of 1 N sodium hydroxide and 300 mg of hydroxy naphthol blue, and continue the titration to a blue endpoint. Each mL of 0.05 M edetate disodium is equivalent to 24.52 mg of C14H26CaO16.
Auxiliary Information
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Chromatographic Column
USP32NF27 Page 1763
Pharmacopeial Forum: Volume No. 27(6) Page 3257
Chromatographic columns text is not derived from, and not part of, USP 32 or NF 27.
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