Calcium Pantothenate
476.53
-Alanine, N-(2,4-dihydroxy-3,3-dimethyl-1-oxobutyl)-, calcium salt (2:1), (R)-.
Calcium d-pantothenate (1:2)
[137-08-6].» Calcium Pantothenate is the calcium salt of the dextrorotatory isomer of pantothenic acid. It contains not less than 5.7 percent and not more than 6.0 percent of nitrogen (N), and not less than 8.2 percent and not more than 8.6 percent of calcium (Ca), both calculated on the dried basis.
Packaging and storage—
Preserve in tight containers.
Identification—
B:
A solution (1 in 20) responds to the tests for Calcium 
191
.
191.
Alkalinity—
Dissolve 1.0 g in 15 mL of carbon dioxide-free water in a small flask. As soon as solution is complete, add 1.0 mL of 0.10 N hydrochloric acid, then add 0.05 mL of phenolphthalein TS, and mix: no pink color is produced within 5 seconds.
Loss on drying 731—
Dry it at 105
for 3 hours: it loses not more than 5.0% of its weight.
731—
Dry it at 105 for 3 hours: it loses not more than 5.0% of its weight.
Heavy metals 231—
Dissolve 1.0 g in 25 mL of water: the limit is 0.002%.
231—
Dissolve 1.0 g in 25 mL of water: the limit is 0.002%.
Ordinary impurities 466—
466—
Test solution:
water.
Standard solution:
water. Use USP Beta Alanine RS, in place of USP Calcium Pantothenate RS, as the Standard.
Eluant:
a mixture of alcohol and water (65:35).
Visualization:
4.
Limit:
1.0%.
Nitrogen content, Method I 461—
Proceed as directed except to weigh accurately about 500 mg.
461—
Proceed as directed except to weigh accurately about 500 mg.
Content of calcium
—Dissolve about 800 mg of Calcium Pantothenate, accurately weighed, in 150 mL of water containing 2 mL of 3 N hydrochloric acid. Add 15 mL of 1 N sodium hydroxide and 300 mg of hydroxy naphthol blue, and titrate with 0.05 M edetate disodium VS until the solution is a distinct blue in color. Each mL of 0.05 M edetate disodium is equivalent to 2.004 mg of Ca.
Auxiliary Information—
Please check for your question in the FAQs before contacting USP.
Chromatographic Column—
| Topic/Question | Contact | Expert Committee |
| Monograph | Curtis Phinney
1-301-816-8540 |
(DSN05) Dietary Supplements - Non-Botanicals |
| Reference Standards | Lili Wang, Technical Services Scientist 1-301-816-8129 RSTech@usp.org |
USP32–NF27 Page 1768
Pharmacopeial Forum: Volume No. 32(1) Page 62
Chromatographic columns text is not derived from, and not part of, USP 32 or NF 27.