Sodium Chromate Cr 51 Injection
Chromic acid (H251CrO4), disodium salt. Disodium chromate (Na251CrO4) ![]() ![]() ![]() » Sodium Chromate Cr 51 Injection is a sterile solution of radioactive chromium (51Cr) processed in the form of sodium chromate in Water for Injection. For those uses where an isotonic solution is required, Sodium Chloride may be added in appropriate amounts as provided under Injections
![]() ![]() Sodium Chromate Cr 51 Injection contains not less than 90.0 percent and not more than 110.0 percent of the labeled amount of 51Cr as sodium chromate expressed in megabecquerels (millicuries) per mL at the time indicated in the labeling. The sodium chromate content is not less than 90.0 percent and not more than 110.0 percent of the labeled amount. The specific activity is not less than 370 megabecquerels (10 millicuries) per mg of sodium chromate at the end of the expiry period. Other chemical forms of radioactivity do not exceed 10.0 percent of the total radioactivity.
Packaging and storage
Preserve in single-dose or in multiple-dose containers.
Labeling
Label it to include the following, in addition to the information specified for Labeling under Injections
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USP Reference standards
![]() ![]() USP Endotoxin RS.
Radionuclide identification (see Radioactivity
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Bacterial endotoxins
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pH
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Radiochemical purity
Place a volume of Injection, appropriately diluted so that it provides a count rate of about 20,000 counts per minute, about 25 mm from one end of a 25- × 300-mm strip of chromatographic paper (see Chromatography
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Other requirements
It meets the requirements under Injections
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Assay for sodium chromate
Standard stock preparation
Dissolve 3.735 g of potassium chromate in 1000 mL of water to obtain a solution having a known concentration of 1.0 mg per mL of chromium.
Standard preparation
Pipet 0.25, 0.50, 0.75, 0.100, 0.125, and 0.150 mL of the Standard stock preparation, accurately measured, into separate 100-mL volumetric flasks. To each flask add 0.42 mL of 0.1 N sodium bicarbonate, and dilute with water to volume to obtain solutions having final concentrations of 0.25, 0.50, 0.75, 1.00, 1.25, and 1.50 µg of chromium per mL.
Assay preparation
Use the Injection.
Blank preparation
Transfer 0.42 mL of 0.1 N sodium bicarbonate to a 100-mL volumetric flask, and dilute with water to volume.
Procedure
Concomitantly determine the absorbances of the Assay preparation, the Standard preparations, and the Blank preparation at the chromium emission line at 357.7 nm with a suitable atomic absorption spectrophotometer (see Spectrophotometry and Light-Scattering
![]() ![]() 3.115C
in which 3.115 is the conversion factor.
Assay for radioactivity
Using a suitable counting assembly (see Selection of a Counting Assembly under Radioactivity
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Auxiliary Information
Please check for your question in the FAQs before contacting USP.
USP32NF27 Page 1927
Pharmacopeial Forum: Volume No. 27(3) Page 2526
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