Enflurane
Ethane, 2-chloro-1-(difluoromethoxy)-1,1,2-trifluoro-, (±)-. (±)-2-Chloro-1,1,2-trifluoroethyl difluoromethyl ether ![]() ![]() ![]() » Enflurane contains not less than 99.9 percent and not more than 100.0 percent of C3H2ClF5O.
Packaging and storage—
Preserve in tight, light-resistant containers, and avoid exposure to excessive heat.
Identification—
The IR absorption spectrum of a thin film of it exhibits maxima only at the same wavelengths as that of a similar preparation of USP Enflurane RS.
Specific gravity
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Refractive index
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Acidity or alkalinity—
Shake 20 mL with 20 mL of carbon dioxide-free water for 3 minutes, and allow the layers to separate: the aqueous layer requires not more than 0.10 mL of 0.010 N sodium hydroxide or not more than 0.60 mL of 0.010 N hydrochloric acid for neutralization, bromocresol purple TS being used as the indicator.
Water, Method I
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Limit of nonvolatile residue—
Allow 10.0 mL to evaporate at room temperature in a tared evaporating dish, and dry the residue at 50
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Chloride
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Limit of fluoride ions—
[note—Use plasticware throughout this test.]
pH 5.25 buffer—
Dissolve 110 g of sodium chloride and 1 g of sodium citrate in 700 mL of water in a 2000-mL volumetric flask. Cautiously add 150 g of sodium hydroxide, and dissolve with shaking. Cool to room temperature, and, while stirring, cautiously add 450 mL of glacial acetic acid to the cooled solution. Cool, add 600 mL of isopropyl alcohol, dilute with water to volume, and mix: the pH of this solution is between 5.0 and 5.5.
Standard stock solution—
Transfer 221 mg of sodium fluoride, previously dried at 150
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Standard solutions—
Dilute portions of the Standard stock solution quantitatively and stepwise with pH 5.25 buffer to obtain 100-mL solutions having concentrations of 1, 3, 5, and 10 µg per mL.
Test solution—
Shake 25 mL with 25 mL of water for 5 minutes, and allow the liquids to separate completely. Transfer 5.0 mL of the water layer to a 10-mL volumetric flask, dilute with pH 5.25 buffer to volume, and mix.
Procedure—
Concomitantly measure the potential (see Titrimetry
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Assay—
Inject a volume of Enflurane of suitable size, but not more than 30 µL, into a suitable gas chromatograph (see Gas Chromatography under Chromatography
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Auxiliary Information—
Please check for your question in the FAQs before contacting USP.
Chromatographic Column—
USP32–NF27 Page 2252
Chromatographic columns text is not derived from, and not part of, USP 32 or NF 27.
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