Methoxyflurane
Ethane, 2,2-dichloro-1,1-difluoro-1-methoxy-. 2,2-Dichloro-1,1-difluoroethyl methyl ether ![]() ![]() ![]() » Methoxyflurane contains not less than 99.9 percent and not more than 100.0 percent of C3H4Cl2F2O. It may contain a suitable stabilizer.
Packaging and storage
Preserve in tight, light-resistant containers, and avoid exposure to excessive heat.
Identification
A:
The IR absorption spectrum of a 1 in 20 solution in chloroform exhibits maxima only at the same wavelengths as that of a similar solution of USP Methoxyflurane RS.
B:
To 1 mL in a test tube add 1 mL of sulfuric acid: the specimen forms a layer over the acid (distinction from halothane).
C:
Cautiously heat the contents of the test tube from Identification test B with agitation: the interface disappears, and hydrofluoric acid is evolved (distinction from chloroform, trichloroethylene, and halothane).
Specific gravity
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Acidity
Shake 25 mL with 25 mL of carbon dioxide-free water for 2 minutes, and allow the layers to separate. Add 1 drop of methyl red TS to the water extract, boil for 1 minute, and titrate with 0.010 N sodium hydroxide: not more than 0.50 mL of 0.010 N sodium hydroxide is required to produce a distinct yellow color.
Water, Method I
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Limit of nonvolatile residue
Allow 50 mL to evaporate at room temperature in a tared evaporating dish, and dry the residue at 105
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Assay
Inject a volume of Methoxyflurane (30 µL or less) into a suitable gas chromatograph (see Chromatography
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Auxiliary Information
Please check for your question in the FAQs before contacting USP.
USP32NF27 Page 2933
Pharmacopeial Forum: Volume No. 31(5) Page 1388
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