Protriptyline Hydrochloride
5H-Dibenzo[a,d]cycloheptene-5-propanamine, N-methyl-, hydrochloride. N-Methyl-5H-dibenzo[a,d]cycloheptene-5-propylamine hydrochloride ![]() ![]() ![]() » Protriptyline Hydrochloride contains not less than 99.0 percent and not more than 101.0 percent of C19H21N·HCl, calculated on the dried basis.
Packaging and storage—
Preserve in well-closed containers.
USP Reference standards
![]() ![]() USP Protriptyline Hydrochloride RS.
Identification—
Solution:
10 µg per mL.
Medium:
0.1 N methanolic hydrochloric acid.
Absorptivities at 292 nm, calculated on the dried basis, do not differ by more than 3.0%.
C:
It responds to the test for Chloride
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D:
Its X-ray diffraction pattern (see X-ray Diffraction
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pH
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Loss on drying
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Residue on ignition
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Heavy metals, Method II
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Assay—
Transfer about 700 mg of Protriptyline Hydrochloride, accurately weighed, to a 125-mL conical flask, and dissolve in 30 mL of glacial acetic acid. Add crystal violet TS and 10 mL of mercuric acetate TS, and titrate with 0.1 N perchloric acid VS to a green endpoint. Perform a blank determination, and make any necessary correction. Each mL of 0.1 N perchloric acid is equivalent to 29.98 mg of C19H21N·HCl.
Auxiliary Information—
Please check for your question in the FAQs before contacting USP.
Chromatographic Column—
USP32–NF27 Page 3437
Chromatographic columns text is not derived from, and not part of, USP 32 or NF 27.
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