Sodium Acetate
Acetic acid, sodium salt, trihydrate. Sodium acetate trihydrate ![]() ![]() ![]() Anhydrous 82.03 ![]() ![]() ![]() » Sodium Acetate contains three molecules of water of hydration, or is anhydrous. It contains not less than 99.0 percent and not more than 101.0 percent of C2H3NaO2, calculated on the dried basis.
Packaging and storage
Preserve in tight containers.
Labeling
Label it to indicate whether it is the trihydrate or is anhydrous. Where Sodium Acetate is intended for use in hemodialysis, it is so labeled.
pH
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Loss on drying
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Insoluble matter
Dissolve the equivalent of 20 g of anhydrous sodium acetate in 150 mL of water, heat to boiling, and digest in a covered beaker on a steam bath for 1 hour. Filter through a tared filtering crucible, wash thoroughly, and dry at 105
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Chloride
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Sulfate
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Calcium and magnesium
To 20 mL of a solution containing the equivalent of 10 mg of anhydrous sodium acetate per mL add 2 mL each of 6 N ammonium hydroxide, ammonium oxalate TS, and dibasic sodium phosphate TS: no turbidity is produced within 5 minutes.
Potassium
Dissolve the equivalent of 3 g of anhydrous sodium acetate in 5 mL of water, add 1 N acetic acid dropwise until the solution is slightly acidic, and then add 5 drops of sodium cobaltinitrite TS: no precipitate is formed.
Aluminum
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Heavy metals, Method I
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Assay
Weigh accurately the equivalent of about 200 mg of anhydrous sodium acetate, and dissolve in 25 mL of glacial acetic acid, warming gently if necessary to effect complete solution. Add 2 drops of p-naphtholbenzein TS, and titrate with 0.1 N perchloric acid VS. Perform a blank determination, and make any necessary correction. Each mL of 0.1 N perchloric acid is equivalent to 8.203 mg of C2H3NaO2.
Auxiliary Information
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Chromatographic Column
USP32NF27 Page 3561
Pharmacopeial Forum: Volume No. 29(5) Page 1576
Chromatographic columns text is not derived from, and not part of, USP 32 or NF 27.
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