Bisacodyl
361.39Phenol, 4,4¢-(2-pyridinylmethylene)bis-, diacetate (ester).
4,4¢-(2-Pyridylmethylene)diphenol diacetate (ester)
[603-50-9].» Bisacodyl contains not less than 98.0 percent and not more than 101.0 percent of C22H19NO4, calculated on the dried basis.
Caution—Avoid inhalation and contact with the eyes, skin, and mucous membranes.
Packaging and storage—
Preserve in well-closed containers.
Identification—
A:
Infrared Absorption 
197S
—
197S—
Cell:
1.0 mm.
Solution:
1 in 200 solution in chloroform, previously dried.
B:
Ultraviolet Absorption 197U—
197U—
Solution:
20 µg per mL.
Medium:
0.05 N hydrochloric acid.
Absorptivities at 263 nm, calculated on the dried basis, do not differ by more than 3.0%.
Loss on drying 731—
Dry it at 105
for 2 hours: it loses not more than 0.5% of its weight.
731—
Dry it at 105 for 2 hours: it loses not more than 0.5% of its weight.
Residue on ignition 281:
not more than 0.1%.
281:
not more than 0.1%.
Heavy metals, Method II 231:
0.001%.
231:
0.001%.
Assay—
Dissolve about 250 mg of Bisacodyl, accurately weighed, in 70 mL of glacial acetic acid, add 3 drops of p-naphtholbenzein TS, and titrate with 0.1 N perchloric acid VS. Perform a blank determination, and make any necessary correction. Each mL of 0.1 N perchloric acid is equivalent to 36.14 mg of C22H19NO4.
Auxiliary Information—
Please check for your question in the FAQs before contacting USP.
| Topic/Question | Contact | Expert Committee |
| Monograph | Elena Gonikberg, Ph.D.
Senior Scientist 1-301-816-8251 |
(MDGRE05) Monograph Development-Gastrointestinal Renal and Endocrine |
| Reference Standards | Lili Wang, Technical Services Scientist 1-301-816-8129 RSTech@usp.org |
USP32–NF27 Page 1682