Tartaric Acid
C4H6O6 150.09
Butanedioic acid, 2,3-dihydroxy-;
Butanedioic acid, 2,3-dihydroxy-, [R-(R*,R*)]-;
Tartaric acid; l-(+)-Tartaric acid
[526-83-0; 87-69-4].
(tar tar' ik as' id).
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C4H6O6 150.09
Butanedioic acid, 2,3-dihydroxy-;
Butanedioic acid, 2,3-dihydroxy-, [R-(R*,R*)]-;
Tartaric acid; l-(+)-Tartaric acid
[526-83-0; 87-69-4].DEFINITION
Tartaric Acid, dried over phosphorus pentoxide for 3 h, contains NLT 99.7% and NMT 100.5% of C4H6O6.
IDENTIFICATION
• A. Identification Tests—General, Tartrate 
191
:
It meets the requirements.
191:
It meets the requirements.
ASSAY
• Procedure
Sample:
2 g of Tartaric Acid, previously dried, in a conical flask
Analysis:
Dissolve the Sample in 40 mL of water, add phenolphthalein TS, and titrate with 1 N sodium hydroxide VS. Each mL of 1 N sodium hydroxide is equivalent to 75.04 mg of C4H6O6.
Acceptance criteria:
99.7%–100.5%
IMPURITIES
Inorganic Impurities
• Residue on Ignition 281:
NMT 0.1%
281:
NMT 0.1%
• Chloride and Sulfate, Sulfate 221:
221:
Sample solution:
10 mL of a 1-in-100 solution of Tartaric Acid
Analysis:
Add to the Sample solution 3 drops of hydrochloric acid and 1 mL of barium chloride TS.
Acceptance criteria:
No turbidity is produced.
• Heavy Metals, Method II 231:
NMT 10 ppm
231:
NMT 10 ppm
SPECIFIC TESTS
to +13.0
• Loss on Drying 731:
Dry over phosphorus pentoxide for 3 h: it loses NMT 0.5% of its weight.
731:
Dry over phosphorus pentoxide for 3 h: it loses NMT 0.5% of its weight.
• Limit of Oxalate
Sample solution:
10 mL of a 1-in-10 solution of Tartaric Acid
Analysis:
Nearly neutralize the Sample solution with 6 N ammonium hydroxide, and add 10 mL of calcium sulfate TS.
Acceptance criteria:
No turbidity is produced.
ADDITIONAL REQUIREMENTS
• Packaging and Storage:
Preserve in well-closed containers.
• USP Reference Standards 11
11
USP Tartaric Acid RS 
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Auxiliary Information—
Please check for your question in the FAQs before contacting USP.
| Topic/Question | Contact | Expert Committee |
|---|---|---|
| Monograph | Robert H. Lafaver, M.S.
Scientific Liaison 1-301-816-8335 |
(EXC2010) Monographs - Excipients |
| Reference Standards | RS Technical Services 1-301-816-8129 rstech@usp.org |
USP35–NF30 Page 2004
Pharmacopeial Forum: Volume No. 35(5) Page 1212