Title: 2-Methylaminoethanol
CAS Registry Number: 109-83-1
Additional Names: Methyl(b-hydroxyethyl)amine; methylethylolamine
Molecular Formula: C3H9NO
Molecular Weight: 75.11
Percent Composition: C 47.97%, H 12.08%, N 18.65%, O 21.30%
Line Formula: CH3NHCH2CH2OH
Literature References: In vivo precursor of choline; isoln from mutant of Neurospora crassa which has lost its ability to synthesize choline: Horowitz, J. Biol. Chem. 162, 413 (1946). Prepn by mixing ethylene oxide with concd methylamine soln with external cooling: Knorr, Matthes, Ber. 31, 1069 (1898); Lowe et al., GB 763434 (1956 to Oxirane Ltd.); Nikolaev et al., Zh. Obshch. Khim. 33, 391 (1963). Toxicity studies: R. Hartung, H. H. Cornish, Toxicol. Appl. Pharmacol. 12, 486 (1968); B. Ballantyne, H.-W. Leung, Vet. Hum. Toxicol. 38, 422 (1996).
Properties: Viscous liquid. Fishy odor. d20 0.937. bp760 155-156°; bp12 64-65°. nD20 1.4385. Miscible with water, alcohol, ether. Strong base. Corrosive to cork, metals. LD50 in rats (g/kg): 3.36 orally, 1.33 i.p. (Hartung). LD50 in male, female rats (mg/kg): 1908, 1391 orally; male, female rabbits (mg/kg): 1880, 1006 dermally (Ballantyne, Leung).
Boiling point: bp760 155-156°; bp12 64-65°
Index of refraction: nD20 1.4385
Density: d20 0.937
Toxicity data: LD50 in rats (g/kg): 3.36 orally, 1.33 i.p. (Hartung); LD50 in male, female rats (mg/kg): 1908, 1391 orally; male, female rabbits (mg/kg): 1880, 1006 dermally (Ballantyne, Leung)
CAUTION: Direct contact may cause skin and eye irritation, skin corrosioin. See Ballantyne, Leung. |