Title: Acetarsone
CAS Registry Number: 97-44-9
CAS Name: [3-(Acetylamino)-4-hydroxyphenyl]arsonic acid
Additional Names: N-acetyl-4-hydroxy-m-arsanilic acid; 3-acetamido-4-hydroxyphenylarsonic acid; 3-acetamido-4-hydroxybenzenearsonic acid; acetarsol; acetphenarsine
Manufacturers' Codes: Ehrlich 594; Fourneau 190; F-190
Trademarks: Gynoplix (Thaplix); Orarsan (Boots); Spirocid (Hoechst); Stovarsol (Abbott)
Molecular Formula: C8H10AsNO5
Molecular Weight: 275.09
Percent Composition: C 34.93%, H 3.66%, As 27.24%, N 5.09%, O 29.08%
Literature References: Pentavalent arsenical formerly used in the treatment of syphilis. Also used in combination with arecoline, q.v. Prepn: Raiziss, Fisher, J. Am. Chem. Soc. 48, 1323 (1926); Hewitt, King, J. Chem. Soc. 1926, 823. Toxicity data: H. H. Anderson, C. D. Leake, Proc. Soc. Exp. Biol. Med. 27, 267 (1930).
Properties: Stout prisms from water, dec 240-250°; slight acid taste. Slightly sol in water; freely sol in solns of alkalies and alkali carbonates. Stable at ordinary temps. MLD in rabbits, cats (mg/kg): 125-150, 150-175 orally (Anderson, Leake).
Toxicity data: MLD in rabbits, cats (mg/kg): 125-150, 150-175 orally (Anderson, Leake)
Therap-Cat: Antiprotozoal (Trichomonas).
Therap-Cat-Vet: Antiprotozoal.
Keywords: Antiprotozoal (Trichomonas). |