Title: Antimony Potassium Tartrate
CAS Registry Number: 28300-74-5
CAS Name: Dipotassium bis[m-[2,3-dihydroxybutanedioato(4-)-01,02:03,04]]diantimonate(2-) trihydrate stereoisomer
Additional Names: tartar emetic; tartrated antimony; tartarized antimony; potassium antimonyltartrate
Molecular Formula: C8H4K2O12Sb2.3H2O
Molecular Weight: 667.87
Percent Composition: C 14.39%, H 1.51%, K 11.71%, O 35.93%, Sb 36.46%
Literature References: Manuf from potassium bitartrate and metallic antimony in the presence of HNO3 or solid antimony oxide: Davies, US 2335585 (1943 to Am. Cream Tartar); US 2391297 (1945 to Stauffer Chem.). Structural studies: P. Pfeiffer, E. Schmitz, Pharmazie 4, 451 (1949); E. Chinoporos, N. Papathanasopoulos, J. Phys. Chem. 65, 1643 (1961); D. Grdenic, B. Kamenar, Acta Crystallogr. 19, 197 (1965); R. Iyer et al., J. Inorg. Nucl. Chem. 34, 3351 (1972). Toxicity: N. Ercoli, Proc. Soc. Exp. Biol. Med. 129, 284 (1968). Anthelmintic activity: Z. Farid et al., Trans. R. Soc. Trop. Med. Hyg. 66, 119 (1972); R. R. C. New et al., Nature 272, 56 (1978). Oxidimetric determn: Y. A. Gawargious et al., Pharmazie 41, 59 (1980).
Properties: Transparent crystals (effloresce on exposure to air) or powder. Sweetish, metallic taste. Poisonous! d 2.6. [a]D20 +140.69° (c = 2 in water), +139.25° (c = 2 in glycerol). One gram dissolves in 12 ml water, 3 ml boiling water, 15 ml glycerol. Insol in alcohol. The aq soln is slightly acid. LD50 in mice (mg/kg): 55 s.c.; 65 i.v. (Ercoli). Incompat. Mineral acids, tannic acid, gallic acids, alkali hydroxides and carbonates, lead and silver salts, mercury bichloride, lime water, albumin, soap.
Optical Rotation: [a]D20 +140.69° (c = 2 in water), +139.25° (c = 2 in glycerol)
Density: d 2.6
Toxicity data: LD50 in mice (mg/kg): 55 s.c.; 65 i.v. (Ercoli)
Use: As mordant in the textile and leather industry.
Therap-Cat: Anthelmintic (Schistosoma).
Therap-Cat-Vet: Has been used as a parasiticide (gastrointestinal and blood parasites); as an expectorant, and as a ruminatoric.
Keywords: Anthelmintic (Schistosoma). |