Title: Benzoyl Peroxide
CAS Registry Number: 94-36-0
CAS Name: Dibenzoyl peroxide
Additional Names: benzoyl superoxide
Trademarks: Acetoxyl (Stiefel); Acnegel (Stiefel); Akneroxid L (Lubapharm); Benoxyl (Stiefel); Benzac (Galderma); Benzagel (RPR); Benzaknen (Galderma); Brevoxyl (Stiefel); Debroxide (Alcon); Desanden (Nycomed); Lucidol (Elf Atochem); Nericur (Schering); Oxy-5 (SKB); PanOxyl (Stiefel); Peroxyderm (Chassot); Persa-gel (J & J); Sanoxit (Galderma); Theraderm (BMS); Xerac BP (Person & Covey)
Molecular Formula: C14H10O4
Molecular Weight: 242.23
Percent Composition: C 69.42%, H 4.16%, O 26.42%
Line Formula: (C6H5CO)2O2
Literature References: Prepd by interaction of benzoyl chloride and a cooled soln of sodium peroxide. Laboratory procedure: A. I. Vogel, Practical Organic Chemistry (Longmans, London, 3rd ed., 1954) p 807; Gattermann-Wieland, Praxis des Organischen Chemikers (de Gruyter, Berlin, 40th ed., 1961) p 115. Comparative clinical study with clindamycin, q.v., in acne vulgaris: L. J. Swinyer et al., Br. J. Dermatol. 119, 615 (1988). Review of carcinogenic and allergenic potential: D. J. Hogan, Int. J. Dermatol. 30, 467-470 (1991).
Properties: Crystals. mp 103-106°. May explode when heated. Sparingly sol in water or alcohol; sol in benzene, chloroform, ether. One gram dissolves in 40 ml carbon disulfide, in about 50 ml olive oil.
Melting point: mp 103-106°
CAUTION: Potential symptoms of overexposure are irritation of skin, eyes and mucous membranes; sensitization dermatitis. See NIOSH Pocket Guide to Chemical Hazards (DHHS/NIOSH 97-140, 1997) p 26.
Use: Source of free radicals for industrial processes. Oxidizing agent in bleaching oils, flour, etc.; catalyst in the plastics industry; initiator in polymerization.
Therap-Cat: Keratolytic.
Therap-Cat-Vet: Keratolytic.
Keywords: Antiacne; Keratolytic. |