Title: Brimonidine
CAS Registry Number: 59803-98-4
CAS Name: 5-Bromo-N-(4,5-dihydro-1H-imidazol-2-yl)-6-quinoxalinamine
Additional Names: 5-bromo-6-(2-imidazolin-2-ylamino)quinoxaline
Manufacturers' Codes: UK-14304; AGN-190342
Molecular Formula: C11H10BrN5
Molecular Weight: 292.13
Percent Composition: C 45.23%, H 3.45%, Br 27.35%, N 23.97%
Literature References: a2-Adrenoceptor agonist. Prepn: J. C. Danielewicz et al., DE 2309160; eidem, US 3890319 (1973, 1975 both to Pfizer). HPLC determn in serum and aqueous humour of the eye: N. K. Karamanos et al., Biomed. Chromatogr. 13, 86 (1999). Clinical study in control of intraocular pressure: R. David et al., Arch. Ophthalmol. 111, 1387 (1993); L. J. Katz et al., Am. J. Ophthalmol. 127, 20 (1999). Review of pharmacology and mechanisms of action: J. C. Adkins, J. A. Balfour, Drugs Aging 12, 225-241 (1998); of pharmacotherapeutic profile: L. B. Cantor, Expert Opin. Pharmacother. 1, 815-834 (2000).
Properties: Yellow crystals from ethanol, mp 252°.
Melting point: mp 252°
Derivative Type: D-Tartrate
CAS Registry Number: 70359-46-5
Manufacturers' Codes: UK-14304-18; AGN-190342-LF
Trademarks: Alphagan (Allergan)
Molecular Formula: C11H10BrN5.C4H6O6
Molecular Weight: 442.22
Percent Composition: C 40.74%, H 3.65%, Br 18.07%, N 15.84%, O 21.71%
Properties: White crystals from acetone, mp 207.5°.
Melting point: mp 207.5°
Therap-Cat: Antiglaucoma.
Keywords: Antiglaucoma. |