Title: Calcium Acetylsalicylate
CAS Registry Number: 69-46-5
CAS Name: 2-(Acetyloxy)benzoic acid calcium salt
Additional Names: salicylic acid acetate calcium salt; acetylsalicylic acid calcium salt; calcium aspirin; soluble aspirin
Trademarks: Cal-Aspirin (Winthrop); Dispril; Disprin; Kalmopyrin; Kalsetal; Solaspin (Indian Health); Tylcalsin
Molecular Formula: C18H14CaO8
Molecular Weight: 398.38
Percent Composition: C 54.27%, H 3.54%, Ca 10.06%, O 32.13%
Line Formula: Ca(OOCC6H4OCOCH3)2
Literature References: Prepd from calcium carbonate and acetylsalicylic acid: Lawrence, US 2003374 (1935 to Lee Labs.).
Derivative Type: Dihydrate
Properties: Amorphous, nonhygroscopic powder. One gram dissolves in 6 ml water, 80 ml alcohol.
Derivative Type: Complex with urea
CAS Registry Number: 5749-67-7
Additional Names: Carbasalate calcium; acetylsalicylic acid calcium salt complex with urea; calcium acetylsalicylate carbamide; urea calcium acetylsalicylate; carbaspirin calcium
Trademarks: Alcacyl (Novartis); Ascal (Viatris); Calurin (Dorsey); Cardiosolupsan (BMS); Solupsan (UPSA)
Molecular Formula: C19H18CaN2O9
Molecular Weight: 458.43
Percent Composition: C 49.78%, H 3.96%, Ca 8.74%, N 6.11%, O 31.41%
Literature References: Description and hydrolytic stability: Parrott, J. Pharm. Sci. 51, 897 (1962). Clinical trial in migraine: C. Le Jeunne et al., Eur. Neurol. 41, 37 (1999).
Properties: Amorphous powder, dec 243-245°. Soly in water at 37°: 231 mg/ml, pH 4.8.
Therap-Cat: Analgesic; antipyretic; anti-inflammatory.
Keywords: Analgesic (Non-Narcotic); Anti-inflammatory (Nonsteroidal); Salicylic Acid Derivatives; Antipyretic. |