Calfactant

Literature References: Chloroform/methanol extract of calf lung lavage fluid. Consists of 35 mg/ml phospholipid, 55-70% of which is dipalmitoylphosphatidylcholine, and of low mol wt surfactant proteins. Also contains 0.9 mg/ml fatty acids and 1.8 mg/ml neutral lipids. See also: Beractant, Poractant Alfa. Prepn: R. H. Notter et al., Pediatr. Res. 16, 515 (1982). Physiologic effects in preterm lambs: J. J. Cummings et al., Am. Rev. Respir. Dis. 145, 999 (1992). Surface tension: E. M. Scarpelli et al., Am. J. Perinatol. 9, 414 (1992). Separation of hydrophobic constituents: S. B. Hall et al., J. Lipid Res. 35, 1386 (1994). Clinical trial in neonates: M. S. Kwong et al., Pediatrics 76, 585 (1985). Efficacy of prophylactic administration to neonates: J. Kattwinkel et al., ibid. 92, 90 (1993). Clinical trial in pediatric acute lung injury: D. F. Wilson et al., J. Am. Med. Assoc. 293, 470 (2005).