Title: Cetraxate
CAS Registry Number: 34675-84-8
CAS Name: 4-[[[trans-4-(Aminomethyl)cyclohexyl]carbonyl]oxy]benzenepropanoic acid
Additional Names: p-hydroxyhydrocinnamic acid trans-(4-aminomethyl)cyclohexanecarboxylate; tranexamic acid p-(2-carboxyethyl)phenyl ester
Molecular Formula: C17H23NO4
Molecular Weight: 305.37
Percent Composition: C 66.86%, H 7.59%, N 4.59%, O 20.96%
Literature References: Deriv of tranexamic acid, q.v. Prepn: Y. Yamamura et al., DE 1951061; eidem, US 3699149 (1970, 1972 both to Daiichi); O. Atsuji et al., J. Med. Chem. 15, 247 (1972); S. Kitahara, JP Kokai 73 75547 (1973 to Daiichi), C.A. 80, 59727x (1974). Mechanism of action: Y. Suzuki et al., Jpn. J. Pharmacol. 29, 829 (1979), C.A. 92, 88029 (1980). Anti-ulcer effects in rats: T. Hashizume et al., Arch. Int. Pharmacodyn. Ther. 240, 314 (1979). Clinical study: A. Ishimori et al., Arzneim.-Forsch. 29, 1625 (1979); S. Yamagata, K. Miura, ibid. 33, 1191 (1983).
Properties: Crystals from methanol, melts over a range of 200-280°.
Melting point: melts over a range of 200-280°
Derivative Type: Hydrochloride
CAS Registry Number: 27724-96-5
Manufacturers' Codes: DV-1006
Trademarks: Neuer (Daiichi)
Molecular Formula: C17H23NO4.HCl
Molecular Weight: 341.83
Percent Composition: C 59.73%, H 7.08%, N 4.10%, O 18.72%, Cl 10.37%
Properties: Crystals from methanol/ether, mp 238-240°.
Melting point: mp 238-240°
Therap-Cat: Antiulcerative.
Keywords: Antiulcerative; Cytoprotectant (Gastric). |