Title: Chromafenozide
CAS Registry Number: 143807-66-3
CAS Name: 3,4-Dihydro-5-methyl-2H-1-benzopyran-6-carboxylic acid 2-(3,5-dimethylbenzoyl)-2-(1,1-dimethylethyl)hydrazide
Additional Names: 2¢-tert-butyl-5-methyl-2¢-(3,5-xyloyl)chromane-6-carbohydrazide
Manufacturers' Codes: ANS-118
Trademarks: Matric (Sankyou Agro)
Molecular Formula: C24H30N2O3
Molecular Weight: 394.51
Percent Composition: C 73.07%, H 7.66%, N 7.10%, O 12.17%
Literature References: Diacylhydrazine ecdysone mimetic for use in food crops. Prepn: M. Yanagi et al., EP 496342; eidem, US 5378726 (1992, 1995 both to Nippon Kayaku; Sankyo). Properties and biological activity: M. Yanagi et al., BCPC Conf. - Pests Dis. 2000, 27. Field trial against apple tortix: R. Ichinose et al., Annu. Rep. Sankyo Res. Lab. 52, 59 (2000). Mode of action: T. Toya et al., Biochem. Biophys. Res. Commun. 292, 1087 (2002). Series of articles on design, synthesis, and activity: Y. Sawada et al., Pest Manage. Sci. 59, 25-57 (2003). Review of development, environmental chemistry, safety, and toxicity: K. Tanaka et al., Annu. Rep. Sankyo Res. Lab. 53, 1-49 (2001).
Properties: White crystalline powder, mp 186.4°. Log P (octanol/water): 2.7 (22°). Vapor pressure at 25°: £4 ´ 10-9 Pa. Soly in water at 20°: 1.12 mg/l. Moderately sol in polar organic solvents. LD50 (mg/kg) orally in rats, mice: >5000; dermally in rabbits: >2000; LC50 (mg/l) in rats: >4.68 by inhalation; in carp, rainbow trout (96 hr): >47.25, >18.9 (Yanagi).
Melting point: mp 186.4°
Log P: Log P (octanol/water): 2.7 (22°)
Toxicity data: LD50 (mg/kg) orally in rats, mice: >5000; dermally in rabbits: >2000; LC50 (mg/l) in rats: >4.68 by inhalation; in carp, rainbow trout (96 hr): >47.25, >18.9 (Yanagi)
Use: Insecticide. |