Title: Clomocycline
CAS Registry Number: 1181-54-0
CAS Name: 7-Chloro-4-(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,6,10,12,12a-pentahydroxy-N-(hydroxymethyl)-6-methyl-1,11-dioxo-2-naphthacenecarboxamide
Additional Names: chlormethylenecycline; N2-(hydroxymethyl)chlortetracycline; N-methylol-7-chlortetracycline
Trademarks: Megaclor (Pharmax)
Molecular Formula: C23H25ClN2O9
Molecular Weight: 508.91
Percent Composition: C 54.28%, H 4.95%, Cl 6.97%, N 5.50%, O 28.29%
Literature References: Semi-synthetic broad spectrum antibiotic related to tetracycline, q.v. Prepn: Banci, Tubaro, Boll. Chim. Farm. 102, 471 (1963); BE 628142 (1963 to AB Leo), C.A. 60, 15805f (1964).
Properties: Yellow material. Dec 145-170°. Sensitive to light and air. pH of 2% aq soln 6.3-6.5. Sol in citrate-phosphate buffer, pH 6-8.
Therap-Cat: Antibacterial.
Keywords: Antibacterial (Antibiotics); Tetracyclines. |