Title: Colesevelam Hydrochloride
CAS Registry Number: 182815-44-7
CAS Name: N,N,N-Trimethyl-6-(2-propenylamino)-1-hexanaminium chloride polymer with (chloromethyl)oxirane, 2-propen-1-amine and N-2-propenyl-1-decanamine, hydrochloride
Manufacturers' Codes: GT-31-104
Trademarks: CholestaGel (GelTex); Welchol (Sankyo)
Literature References: Bile acid sequestrant composed of a polyallylamine cross-linked with epichlorohydrin and alkylated with 1-bromodecane and 6-bromohexyltrimethylammonium bromide. Prepn: H. W. Mandeville, III, S. R. Holmes-Farley, WO 9534585; eidem, US 5693675 (1995, 1997 both to GelTex); and bile acid binding: W. H. Mandeville et al., Mater. Res. Soc. Symp. Proc. 550, 3 (1999). Absorption, distribution and excretion: D. P. Rosenbaum et al., J. Pharm. Sci. 86, 591 (1997). Clinical trial in hypercholesterolemia: W. Insull, Jr. et al., Mayo Clin. Proc. 76, 971 (2001). Review of pharmacology and clinical experience: M. A. Aldridge, M. K. Ito, Ann. Pharmacother. 35, 898-907 (2001).
Therap-Cat: Antilipemic.
Keywords: Antilipemic; Bile Acid Sequesterants. |