Title: Desflurane
CAS Registry Number: 57041-67-5
CAS Name: 2-(Difluoromethoxy)-1,1,1,2-tetrafluoroethane
Additional Names: (±)-2-difluoromethyl 1,2,2,2-tetrafluoroethyl ether
Manufacturers' Codes: I-653
Trademarks: Suprane (Ohmeda)
Molecular Formula: C3H2F6O
Molecular Weight: 168.04
Percent Composition: C 21.44%, H 1.20%, F 67.84%, O 9.52%
Line Formula: CHF2OCHFCF3
Literature References: Prepd but not claimed: J. P. Russell et al., US 3897502 (1975 to Airco). Prepn and use as anesthetic: R. C. Terrell, US 4762856 (1988 to BOC). Series of articles on pharmacology and physical properties: E. I. Eger II et al., Anesth. Analg. 66, 971-985 (1987); and toxicity studies: eidem, ibid. 1227, 1230. Series of articles on clinical pharmacology and kinetics: Anesthesiology 74, 412-439; 479-498. Review: R. M. Jones, Br. J. Anaesth. 65, 527-536 (1990).
Properties: Volatile liquid. Slight non-pungent odor. Nonflammable, soda lime stable. bp 23.5°. d 1.44. Vapor pressure (20°): 88.53 kPa. Vapor pressure (22-23°): ~700mm. Partition coefficient at 37° (blood/gas): 0.424 ±0.024; (saline/gas): 0.225 ±0.002; (oil/gas): 18.7 ±1.1.
Boiling point: bp 23.5°
Log P: Partition coefficient at 37° (blood/gas): 0.424 ±0.024; (saline/gas): 0.225 ±0.002; (oil/gas): 18.7 ±1.1
Density: d 1.44
Therap-Cat: Anesthetic (inhalation).
Keywords: Anesthetic (Inhalation). |