Title: Dextranomer
CAS Registry Number: 56087-11-7
CAS Name: Dextran 2,3-dihydroxypropyl 2-hydroxy-1,3-propanediyl ethers
Trademarks: Debrisan (Pharmacia); Debrisorb (Pharmacia)
Literature References: Three-dimensional hydrophilic network of a dextran polymer, linked by cross-chains of epichlorohydrin, q.v.; it absorbs moisture and small molecules from suppurating wounds. Chronic tissue response to implantation: J. Falk, G. Tollerz, Clin. Ther. 1(3), 185 (1977). Potential allergic contact sensitization in guinea pigs: G. Jonsson, ibid. 1(4), 260 (1978). Efficacy in treatment of ulcers and wounds: J. Soul, Br. J. Clin. Pract. 32, 172 (1978); P. N. Sawyer et al., Surgery 85, 201 (1979); S. Di Mascio, Am. J. Nurs. 79, 684 (1979). Review: R. C. Heel et al., Drugs 18, 89-102 (1979).
Properties: Insol in all solvents; stable in water, salt solns and in alkaline and weakly acidic soln.
Therap-Cat: Vulnerary.
Keywords: Vulnerary. |