Title: Dronedarone
CAS Registry Number: 141626-36-0
CAS Name: N-[2-Butyl-3-[4-[3-(dibutylamino)propoxy]benzoyl]-5-benzofuranyl]methanesulfonamide
Additional Names: N,N-dibutyl-3-[4-[(2-butyl-5-methylsulfonamido)benzofuran-3-ylcarbonyl]phenoxy]propylamine
Manufacturers' Codes: SR-33589
Molecular Formula: C31H44N2O5S
Molecular Weight: 556.76
Percent Composition: C 66.87%, H 7.97%, N 5.03%, O 14.37%, S 5.76%
Literature References: Noniodinated analog of amiodarone, q.v. Prepn: J. Gubin et al., EP 471609; eidem, US 5223510 (1992, 1993 both to Sanofi). Hemodynamic and antiadrenergic effects in dogs: L. Djandjighian et al., J. Cardiovasc. Pharmacol. 36, 376 (2000). Electrophysiological effects in canine heart: A. Varró et al., Br. J. Pharmacol. 133, 625 (2001). Clinical pharmacokinetics and interaction with metoprolol, q.v.: T. Damy et al., Fundam. Clin. Pharmacol. 18, 113 (2004). Clinical evaluation in atrial fibrillation: P. Touboul et al., Eur. Heart J. 24, 1481 (2003).
Properties: Crystals from hexane, mp 65.3°.
Melting point: mp 65.3°
Derivative Type: Hydrochloride
CAS Registry Number: 141625-93-6
Manufacturers' Codes: SR-33589B
Molecular Formula: C31H45ClN2O5S
Molecular Weight: 593.22
Percent Composition: C 62.76%, H 7.65%, Cl 5.98%, N 4.72%, O 13.49%, S 5.41%
Properties: Colorless solid from acetone, mp 143°.
Melting point: mp 143°
Therap-Cat: Antiarrhythmic (class III).
Keywords: Antiarrhythmic. |