Title: EGTA
CAS Registry Number: 67-42-5
CAS Name: 3,12-Bis(carboxymethyl)-6,9-dioxa-3,12-diazatetradecanedioic acid
Additional Names: [ethylenebis(oxyethylenenitrilo)]tetraacetic acid; ethylene glycol bis(b-aminoethylether)-N,N,N¢,N¢-tetraacetic acid
Molecular Formula: C14H24N2O10
Molecular Weight: 380.35
Percent Composition: C 44.21%, H 6.36%, N 7.37%, O 42.06%
Literature References: Chelating agent. Prepn: H. Schläpfer, J. Bindler, US 2709178 (1955 to Geigy). Toxicology: J. E. Wynn et al., Toxicol. Appl. Pharmacol. 16, 807 (1970). Thermal properties: M. F. G. Esteban et al., Thermochim. Acta 62, 267 (1983). Cathodic-stripping determn: M. Ciszkowska, Z. Stojek, Talanta 33, 817 (1986). Use in calcium measurements: J. D. Johnson et al., Am. J. Physiol. 272, C1437 (1997); in heavy metal remobilization from river sediment: K.-C. Yu et al., Toxicol. Environ. Chem. 58, 85 (1997). Review of regulation of Ca+2 concentration in biological systems: S. Robertson, J. D. Potter, Methods Pharmacol. 5, 63-75 (1984).
Derivative Type: Disodium salt
CAS Registry Number: 26082-78-0
Molecular Formula: C14H22N2Na2O10
Molecular Weight: 424.31
Percent Composition: C 39.63%, H 5.23%, N 6.60%, Na 10.84%, O 37.71%
Properties: LD50 orally in rats: 3.96±0.50 g/kg (Wynn).
Toxicity data: LD50 orally in rats: 3.96±0.50 g/kg (Wynn)
Use: Chelator for heavy metals. Reagent for maintaining calcium concentrations. |