Title: Ethionamide
CAS Registry Number: 536-33-4
CAS Name: 2-Ethyl-4-pyridinecarbothioamide
Additional Names: 2-ethylthioisonicotinamide; 3-ethylisothionicotinamide; 2-ethylisothionicotinamide; 2-ethyl-4-thiocarbamoylpyridine; a-ethylisonicotinoylthioamide; amidazine; ethioniamide
Manufacturers' Codes: Bayer 5312; 1314-Th
Trademarks: Nisotin; Trescatyl (M & B); Aetina; Ethimide; Iridocin (Bayer); Tio-Mid
Molecular Formula: C8H10N2S
Molecular Weight: 166.24
Percent Composition: C 57.80%, H 6.06%, N 16.85%, S 19.29%
Literature References: Prepn: Libermann et al., Compt. Rend. 242, 2409 (1956); Bull. Soc. Chim. Fr. 1958, 687; GB 800250 (1958 to Chimie et Atomistique). Mechanism of action study: K. Johnsson et al., J. Am. Chem. Soc. 117, 5009 (1995).
Properties: Minute yellow crystals from ethanol, dec 164-166°. Very sparingly sol in water, ether. Sparingly sol in methanol, ethanol, propylene glycol. Sol in hot acetone, dichloroethane. Freely sol in pyridine.
Therap-Cat: Antibacterial (tuberculostatic).
Keywords: Antibacterial (Tuberculostatic). |