Title: Etilefrin
CAS Registry Number: 709-55-7
CAS Name: a-[(Ethylamino)methyl]-3-hydroxybenzenemethanol
Additional Names: a-[(ethylamino)methyl]-m-hydroxybenzyl alcohol; m-hydroxy-a-(ethylaminomethyl)benzyl alcohol; a-(m-hydroxyphenyl)-b-(ethylamino)ethanol; ethylphenylephrine; etiladrianol
Molecular Formula: C10H15NO2
Molecular Weight: 181.23
Percent Composition: C 66.27%, H 8.34%, N 7.73%, O 17.66%
Literature References: Sympathomimetic amine. Prepn: T. Goto, J. Pharm. Soc. Jpn. 74, 318 (1954), C.A. 49, 3960 (1955); ES 273595 (1962 to Labs. Fher S.A.), C.A. 60, 1649e (1964). Clinical pharmacology: A. J. Coleman et al., Eur. J. Clin. Pharmacol. 8, 41 (1975). Clinical pharmacokinetics and disposition: J. H. Hengstmann et al., ibid. 9, 179 (1975). HPLC determn in plasma: K. Kojima et al., J. Chromatogr. 525, 210 (1990). Clinical trial in arterial hypotension: T. Taivainen, Acta Anaesthesiol. Scand. 35, 164 (1991); in neurocardiogenic syncope: F. Ammirati et al., Am. J. Cardiol. 86, 472 (2000).
Properties: Crystals, mp 147-148°.
Melting point: mp 147-148°
Derivative Type: Hydrochloride
CAS Registry Number: 534-87-2
Trademarks: Cardanat (Temmler); Circupon (Gepepharm); Effontil (Boehringer, Ing.); Effortil (Boehringer, Ing.); Efortil (Boehringer, Ing.); Kertasin (Merck KGaA); Thomasin (Apogepha)
Molecular Formula: C10H15NO2.HCl
Molecular Weight: 217.69
Percent Composition: C 55.17%, H 7.41%, N 6.43%, O 14.70%, Cl 16.29%
Properties: Crystals, mp 121°. Bitter taste. Freely sol in water; sol in alcohol. Practically insol in chloroform.
Melting point: mp 121°
Therap-Cat: Antihypotensive.
Therap-Cat-Vet: Antihypotensive.
Keywords: Antihypotensive. |