Title: Etoglucid
CAS Registry Number: 1954-28-5
CAS Name: 2,2¢-(2,5,8,11-Tetraoxadodecane-1,12-diyl)bisoxirane
Additional Names: 1,2:15,16-diepoxy-4,7,10,13-tetraoxahexadecane; 1,2-bis[2-(2,3-epoxypropoxy)ethoxy]ethane; triethylene glycol diglycidyl ether; TDE; ethoglucid
Manufacturers' Codes: ICI-32865
Trademarks: Epodyl (Ayerst)
Molecular Formula: C12H22O6
Molecular Weight: 262.30
Percent Composition: C 54.95%, H 8.45%, O 36.60%
Literature References: Prepn: Greenshields et al., GB 901876 (1962 to ICI); Blyakhman, Zh. Org. Khim. 3, 1423 (1967), C.A. 68, 59384k (1968); X.-P. Gu et al., Synthesis 1985, 649. Pharmacology and metabolism: Duncan, Snow, Biochem. J. 82, 8P (1962); James, Solheim, Xenobiotica 1, 43 (1971). Clinical evaluation in bladder tumors: M. R. G. Robinson et al., J. Urol. 118, 972 (1977); J. Flamm, F. Grof, Urologe B27, 26 (1987).
Properties: Colorless liquid, mp -15 to -11°. bp0.005 140°; bp0.1 133-149°; bp2 195-197°. d20 1.1312. nD20 1.4584.
Melting point: mp -15 to -11°
Boiling point: bp0.005 140°; bp0.1 133-149°; bp2 195-197°
Index of refraction: nD20 1.4584
Density: d20 1.1312
Therap-Cat: Antineoplastic.
Keywords: Antineoplastic; Alkylating Agents. |