Title: Fluosol DA
CAS Registry Number: 75216-20-5
Literature References: Biologically inert fluorocarbon emulsion of perfluorodecalin and perfluorotripropylamine that performs the oxygen-carrying function of red blood cells. Has a particle size of 0.05 to 0.25m and is stable at room temperature for years. Can be administered regardless of blood type; does not carry hepatitis or other infectious diseases. Prepn: K. Yokoyama et al., DE 2630586; eidem, US 4252827 (1977, 1981 to Green Cross). Hemodynamic and oxygen transport effects: K. K. Tremper et al., Crit. Care Med. 8, 738 (1980). Clinical studies: H. Ohyanagi et al., Clin. Ther. 2, 306 (1979); T. Suyama et al., Prog. Clin. Biol. Res. 55, 609 (1981); T. Mitsuno et al., Ann. Surg. 195, 60 (1982). Review: Int. Congr. Ser. - Excerpta Med. 486, 1-471 (1979). Review of use as red cell substitute: K. C. Lowe, Comp. Biochem. Physiol. 87A, 825-838 (1987).
Properties: 20% Emulsion, FDA-20. Viscosity at 37°: 2.3 cP. pH 7.4.
Derivative Type: Perfluorodecalin
CAS Registry Number: 306-94-5
CAS Name: Octadecafluorodecahydronaphthalene
Additional Names: perflunafene; FDC
Molecular Formula: C10F18
Molecular Weight: 462.08
Percent Composition: C 25.99%, F 74.01%
Literature References: Prepn: E. T. McBee, L. D. Bechtol, Ind. Eng. Chem. 39, 380 (1947).
Properties: mp -10 to -7°. bp 140°. d420 1.9456. nD20 1.3118. Vapor pressure at 37°: 12.7 mm Hg.
Melting point: mp -10 to -7°
Boiling point: bp 140°
Index of refraction: nD20 1.3118
Density: d420 1.9456
Derivative Type: Perfluorotripropylamine
CAS Registry Number: 338-83-0
CAS Name: 1,1,2,2,3,3,3-Heptafluoro-N,N-bis(heptafluoropropyl)-1-propanamine
Additional Names: heneicosafluorotripropylamine; perfluamine; FTPA
Molecular Formula: C9F21N
Molecular Weight: 521.07
Percent Composition: C 20.75%, F 76.57%, N 2.69%
Literature References: Prepn: R. N. Haszeldine, J. Chem. Soc. 1951, 102.
Properties: bp 129.5-130.5°. d425 1.822. nD25 1.279. Vapor press. at 37°: 20.0 mm Hg.
Boiling point: bp 129.5-130.5°
Index of refraction: nD25 1.279
Density: d425 1.822
Therap-Cat: Blood substitute.
Keywords: Blood Substitute. |