Title: Furazolidone
CAS Registry Number: 67-45-8
CAS Name: 3-[[(5-Nitro-2-furanyl)methylene]amino]-2-oxazolidinone
Additional Names: 3-(5-nitrofurfurylideneamino)-2-oxazolidinone; N-(5-nitro-2-furfurylidene)-3-amino-2-oxazolidone
Manufacturers' Codes: NF-180
Trademarks: Furovag; Furoxane; Furoxone (Eaton); Giarlam; Giardil; Medaron; Neftin; Nicolen; Nifulidone; Ortazol; Roptazol; Tikofuran; Topazone
Molecular Formula: C8H7N3O5
Molecular Weight: 225.16
Percent Composition: C 42.67%, H 3.13%, N 18.66%, O 35.53%
Literature References: Prepn: GB 735136; G. Gever, US 2742462; G. D. Drake et al., US 2759931; G. Gever, C. J. O'Keefe, US 2927110 (1955, 1956, 1956, 1960 all to Norwich); G. Gever et al., J. Am. Chem. Soc. 77, 2277 (1955). LC-MS/MS determn of residues in meat: P. Mottier et al., J. Chromatogr. A 1067, 85 (2005). Antimicrobial spectrum and toxicity: J. A. Yurchenco et al., Antibiot. Chemother. 3, 1035 (1953); G. S. Rogers et al., ibid. 6, 231 (1956). Pharmacology and toxicology: B. H. Ali, Vet. Res. Commun. 6, 1 (1983).
Properties: Yellow crystals from DMF, mp 256-257°. Darkens under strong light. Soly in water (pH 6): approx 40 mg/l. Dec by alkali.
Melting point: mp 256-257°
Therap-Cat: Anti-infective (topical); topical antiprotozoal (Trichmonas).
Therap-Cat-Vet: Antimicrobial.
Keywords: Antiprotozoal (Trichomonas); Antiseptic/Disinfectant; Nitrofurans. |