Title: Glymidine
CAS Registry Number: 339-44-6
CAS Name: N-[5-(2-Methoxyethoxy)-2-pyrimidinyl]benzenesulfonamide
Additional Names: 2-benzenesulfonamido-5-(b-methoxyethoxy)pyrimidine; glycodiazine
Molecular Formula: C13H15N3O4S
Molecular Weight: 309.34
Percent Composition: C 50.47%, H 4.89%, N 13.58%, O 20.69%, S 10.37%
Literature References: Prepn: BE 609270; H. Priewe et al., US 3275635 (1962, 1966 both to Schering, AG); Gutsche et al., Arzneim.-Forsch. 14, 373 (1964). Series of articles on pharmacology: ibid. 377-412. Activity: Losert et al., ibid. 23, 1251 (1973). Metabolism: Soyfer et al., Chim. Ther. 5, 441 (1970). Toxicity data: Kramer et al., Arzneim.-Forsch. 14, 377 (1964).
Properties: Crystals, mp 152-154°. Soly in ethanol: 0.91%; in toluene: 0.67%.
Melting point: mp 152-154°
Derivative Type: Sodium salt
CAS Registry Number: 3459-20-9
Manufacturers' Codes: SH-717
Trademarks: Glyconormal; Gondafon (Schering); Lycanol; Redul (Schering)
Molecular Formula: C13H14N3NaO4S
Molecular Weight: 331.32
Percent Composition: C 47.13%, H 4.26%, N 12.68%, Na 6.94%, O 19.32%, S 9.68%
Properties: Crystals, mp 221-226°. Sparingly sol in alc. Soly in water at 37°: 70.5%. LD50 in mice, rats (g/kg): 1.48, 2.00 i.v.; 5.30, 2.85 orally (Kramer).
Melting point: mp 221-226°
Toxicity data: LD50 in mice, rats (g/kg): 1.48, 2.00 i.v.; 5.30, 2.85 orally (Kramer)
Therap-Cat: Antidiabetic.
Keywords: Antidiabetic; Sulfonylurea Derivatives. |