Title: Grisein
CAS Registry Number: 1391-82-8
Literature References: Antibiotic substance produced by strains of Streptomyces griseus. Isoln: Reynolds et al., Proc. Soc. Exp. Biol. Med. 64, 50 (1947); Reynolds, Waksman, J. Bacteriol. 55, 739 (1948). Improved method of isoln: F. A. Kuehl, L. Chaiet, US 2505053 (1950 to Merck & Co.); F. A. Kuehl et al., J. Am. Chem. Soc. 73, 1770 (1951). Analysis of composition: C40H61FeN10O20S. Degradation of grisein by acid hydrolysis yielded 3-methyluracil and at least two amino acids. One of the acids appears to be glutamic acid: F. A. Kuehl et al., loc. cit. Probably is a mixture of components; similar or identical to albomycin, q.v.: Stapley, Ormond, Science 125, 587 (1957); Turková et al., Collect. Czech. Chem. Commun. 31, 2444 (1966). Toxicity study: V. I. Aksenov, Veterinariya (Moscow) 12, 93 (1974), C.A. 83, 54127d (1975). Biosynthesis: V. V. Kuklin et al., Antibiotiki 25, 403 (1980), C.A. 93, 146173a (1980).
Properties: Amorphous red powder. Sol in water; slightly sol in 95% alcohol. Practically insol in abs alcohol, ether, acetone, chloroform, benzene. The activity remains unchanged when an aq soln is heated to 100° for 10 min. LD50 in mice (mg/kg): 600 orally; 34 s.c. (Aksenov).
Toxicity data: LD50 in mice (mg/kg): 600 orally; 34 s.c. (Aksenov) |