Title: Hycanthone
CAS Registry Number: 3105-97-3
CAS Name: 1-[[2-(Diethylamino)ethyl]amino]-4-(hydroxymethyl)-9H-thioxanthen-9-one
Molecular Formula: C20H24N2O2S
Molecular Weight: 356.48
Percent Composition: C 67.38%, H 6.79%, N 7.86%, O 8.98%, S 8.99%
Literature References: Metabolite of lucanthone, q.v.: Rosi et al., Nature 208, 1005 (1965). Prepn by oxidative fermentation of lucanthone and schistosomicidal activity: Rosi et al., J. Med. Chem. 10, 867 (1967); NL 6410359, and Rosi, Peruzzotti, US 3294803; US 3312598 (1965, 1966, 1967 all to Sterling Drug). Alternate synthesis: Laidlaw et al., J. Org. Chem. 38, 1743 (1973).
Properties: Crystals, mp 100.6-102.8°. Absorption max (ethanol): 233, 258, 329, 438 nm (e 19400, 37000, 9700, 6600). Extremely sensitive to acid.
Melting point: mp 100.6-102.8°
Absorption maximum: Absorption max (ethanol): 233, 258, 329, 438 nm (e 19400, 37000, 9700, 6600)
Derivative Type: Hydrochloride
Properties: mp 173-176° (dec).
Melting point: mp 173-176° (dec)
Derivative Type: Mesylate
CAS Registry Number: 23255-93-8
Trademarks: Etrenol (Winthrop)
Therap-Cat: Anthelmintic (Schistosoma).
Keywords: Anthelmintic (Schistosoma). |