Title: Ibafloxacin
CAS Registry Number: 91618-36-9
CAS Name: 9-Fluoro-6,7-dihydro-5,8-dimethyl-1-oxo-1H,5H-benzo[ij]quinolizine-2-carboxylic acid
Manufacturers' Codes: R-835; S-25930
Molecular Formula: C15H14FNO3
Molecular Weight: 275.27
Percent Composition: C 65.45%, H 5.13%, F 6.90%, N 5.09%, O 17.44%
Literature References: Tricyclic fluorinated quinolone-type antibacterial; related to flumequine, q.v. Prepn: R. M. Stern, EP 109284; idem, US 4472405 (both 1984 to Riker Labs.). Antimicrobial spectrum: L. J. V. Piddock et al., Eur. J. Clin. Microbiol. 5, 303 (1986); K. V. I. Rolston et al., Eur. J. Clin. Microbiol. Infect. Dis. 7, 681 (1988). Synthesis, absolute configuration and antibacterial activity of enantiomers: J. F. Gerster et al., J. Med. Chem. 30, 839 (1987).
Properties: Off-white solid, mp 269-272°.
Melting point: mp 269-272°
Derivative Type: S-Form
Properties: Colorless crystals from DMF, mp 274-276°. [a]D -107.4° (c = 0.1109 g/10mL in dichloroethane).
Melting point: mp 274-276°
Optical Rotation: [a]D -107.4° (c = 0.1109 g/10mL in dichloroethane)
Derivative Type: R-Form
Properties: Colorless crystals from DMF, mp 274-276°. [a]D +106.8° (c = 0.1165 g/10mL in dichloroethane).
Melting point: mp 274-276°
Optical Rotation: [a]D +106.8° (c = 0.1165 g/10mL in dichloroethane)
Therap-Cat-Vet: Antibacterial. |