Title: Ibutilide
CAS Registry Number: 122647-31-8
CAS Name: N-[4-[4-(Ethylheptylamino)-1-hydroxybutyl]phenyl]methanesulfonamide
Molecular Formula: C20H36N2O3S
Molecular Weight: 384.58
Percent Composition: C 62.46%, H 9.44%, N 7.28%, O 12.48%, S 8.34%
Literature References: Methanesulfonanilide antiarrhythmic agent; prolongs myocardial action potential duration, predominantly by activation of slow inward sodium current. Prepn: J. B. Hester, EP 164865; idem, US 5155268 (1985, 1992 both to Upjohn); idem et al., J. Med. Chem. 34, 308 (1991). HPLC determn of enantiomers: C. L. Hsu, R. R. Walters, J. Chromatogr. B 667, 115 (1995); determn of racemate in plasma: L. Tian et al., J. Chromatogr. B 816, 81 (2005). Review of electrophysiology and pharmacology: G. V. Naccarelli et al., Am. J. Cardiol. 78, Suppl. 8A, 12-16 (1996); of pharmacology and clinical potential: R. H. Foster et al., Drugs 54, 312-330 (1997). Clinical trial in atrial flutter or fibrillation: B. S. Stambler et al., Circulation 94, 1613 (1996); J. T. VanderLugt et al., ibid. 100, 369 (1999); in elderly patients: R. M. Gowda et al., Am. J. Ther. 11, 95 (2004).
Derivative Type: Fumarate
CAS Registry Number: 122647-32-9
Manufacturers' Codes: U-70226E
Trademarks: Corvert (Pfizer)
Molecular Formula: (C20H36N2O3S)2.C4H4O4
Molecular Weight: 885.23
Percent Composition: C 59.70%, H 8.65%, N 6.33%, O 18.07%, S 7.24%
Properties: Crystals from acetone, mp 117-119°. uv max (95% ethanol): 228, 267 nm (e 16670, 894) Soly (mg/ml): aqueous >100 (pH £ 7).
Melting point: mp 117-119°
Absorption maximum: uv max (95% ethanol): 228, 267 nm (e 16670, 894)
Therap-Cat: Antiarrhythmic (class III).
Keywords: Antiarrhythmic. |