Title: Iseganan
CAS Registry Number: 257277-05-7
CAS Name: Cyclic (5®14),(7®12)-L-arginylglycylglycyl-L-leucyl-L-cysteinyl-L-tyrosyl-L-cysteinyl-L-arginylglycyl-L-arginyl-L-phenylalanyl-L-cysteinyl-L-valyl-L-cysteinyl-L-valylglycyl-L-argininamide
Manufacturers' Codes: IB-367
Molecular Formula: C78H126N30O18S4
Molecular Weight: 1900.29
Percent Composition: C 49.30%, H 6.68%, N 22.11%, O 15.16%, S 6.75%
Literature References: Cationic antibacterial cyclic peptide composed of 17 amino acid residues with 2 disulfide linkages; synthetic protegrin analog based on the sequence of Protegrin-1 as isolated from porcine neutrophils. Prepn: C. Chang et al., WO 9718826; eidem, US 5994306 (1997, 1999 both to IntraBiotics). CE characterization and purification: J. Chen et al., J. Chromatogr. A 853, 197 (1999). Structure activity study: eidem et al., Biopolymers 55, 88 (2000). In vitro and in vivo antibacterial activity: D. A. Mosca et al., Antimicrob. Agents Chemother. 44, 1803 (2000). Clinical study in oral mucositis: F. J. Giles et al., Leuk. Lymphoma 44, 1165 (2003). Review of pharmacology and clinical experience: idem et al., Expert Opin. Invest. Drugs 11, 1161-1170 (2002).
Derivative Type: Hydrochloride
CAS Registry Number: 256475-21-5; 244015-05-2 (hydrate)
Manufacturers' Codes: IB-367-03
Therap-Cat: Antibacterial.
Keywords: Antibacterial (Antibiotics); Polypeptides. |