Title: Isoconazole
CAS Registry Number: 27523-40-6
CAS Name: 1-[2-(2,4-Dichlorophenyl)-2-[(2,6-dichlorophenyl)methoxy]ethyl]-1H-imidazole
Additional Names: 1-[2,4-dichloro-b-[(2,6-dichlorobenzyl)oxy]phenethyl]imidazole
Molecular Formula: C18H14Cl4N2O
Molecular Weight: 416.13
Percent Composition: C 51.95%, H 3.39%, Cl 34.08%, N 6.73%, O 3.84%
Literature References: Prepn: E. F. Godefroi et al., J. Med. Chem. 12, 784 (1969); eidem, DE 1940388; eidem, US 3717655 and US 3839574 (1970, 1973, 1974 all to Janssen). In vitro activity: H. J. Kessler, Arzneim.-Forsch. 29, 1344 (1979). Animal study: H. J. Kessler et al., ibid. 1352. Antimicrobial activity in humans: H. Wendt, H. J. Kessler, ibid. 846. Bioavailability: U. Täuber, M. Rzadkiewicz, Mykosen 22, 201 (1979).
Derivative Type: Nitrate
CAS Registry Number: 24168-96-5
Manufacturers' Codes: R-15454
Trademarks: Fazol (Schering); Gyno-Travogen (Schering AG); Travogen (Schering AG); Travogyn (Keymer)
Molecular Formula: C18H14Cl4N2O.HNO3
Molecular Weight: 479.14
Percent Composition: C 45.12%, H 3.16%, Cl 29.60%, N 8.77%, O 13.36%
Properties: Solid, mp 182-183°.
Melting point: mp 182-183°
Therap-Cat: Antibacterial; antifungal.
Keywords: Antifungal (Synthetic); Imidazoles. |