Title: Kallidin
CAS Registry Number: 342-10-9
CAS Name: N2-L-Lysylbradykinin
Additional Names: kallidin-10; kallidin II
Molecular Formula: C56H85N17O12
Molecular Weight: 1188.38
Percent Composition: C 56.60%, H 7.21%, N 20.04%, O 16.16%
Literature References: A hypotensive and smooth muscle-stimulating principle formed by the proteolysis of kininogen by glandular and other kallikreins, q.v. The decapeptide structure is a homologue of bradykinin, q.v.: Werle et al., Z. Physiol. Chem. 326, 174 (1961). Synthesis: Nicolaides et al., Biochem. Biophys. Res. Commun. 6, 210 (1961); Pless et al., Helv. Chim. Acta 45, 394 (1962).
Properties: Amorphous precipitate. [a]D21 -57° (c = 1 in N acetic acid). Rf value in a butanol/acetic acid/water system (70:10:20) 0.15.
Optical Rotation: [a]D21 -57° (c = 1 in N acetic acid)
Therap-Cat: Vasodilator.
Keywords: Vasodilator (Peripheral). |