Title: Lofentanil
CAS Registry Number: 61380-40-3
CAS Name: cis-(-)-3-Methyl-4-[(1-oxopropyl)phenylamino]-1-(2-phenylethyl)-4-piperidinecarboxylic acid methyl ester
Additional Names: (-)-cis-3-methyl-1-phenethyl-4-(N-phenylpropionamido)isonipecotic acid methyl ester
Molecular Formula: C25H32N2O3
Molecular Weight: 408.53
Percent Composition: C 73.50%, H 7.90%, N 6.86%, O 11.75%
Literature References: Prepn: P. A. J. Janssen, G. H. P. Van Daele, DE 2610228; eidem, US 3998834 (both 1976 to Janssen). Receptor affinity and pharmacological potency: K. D. Stahl et al., Eur. J. Pharmacol. 46, 199 (1977). Structural study: C. De Ranter et al., Arch. Int. Physiol. Biochim. 87, 1031 (1979). Antinociceptive effects in cats: A. S. Tung, T. L. Yaksh, Pain 12, 343 (1982). Opiate receptor binding studies of 3H-lofentanil: W. Gommeren, J. E. Leysen, Arch. Int. Pharmacodyn. Ther. 258, 171 (1982); B. Ilien et al., ibid. 313; P. M. Laduron, P. Janssen, Life Sci. 31, 457 (1982).
Derivative Type: Oxalate
CAS Registry Number: 61380-41-4
Manufacturers' Codes: R-34995
Molecular Formula: C27H34N2O7
Molecular Weight: 498.57
Percent Composition: C 65.04%, H 6.87%, N 5.62%, O 22.46%
Properties: Solid, mp 177°.
Melting point: mp 177°
Therap-Cat: Analgesic (narcotic).
Keywords: Analgesic (Narcotic). |